A Lyon freshman spent her spring and summer developing small molecules in an organic chemistry research laboratory that could one day be used to treat lung cancer.
Nikkolette Perkins, of Brookland, Ark., researched 1,4-naphthoquinone, an organic compound with significant biological activities, with Associate Professor of Chemistry Dr. Irosha Nawarathne. These biological activities include anticancer, antimicrobial, antiproliferative and anti-inflammatory properties.
Perkins would develop chemical methodologies to make novel modified naphthoquinones by adding groups to the core structure to make effective lung cancer treatments. She used organic reactions, such as Michael addition and click reaction, and organic techniques and instrumentation like analytical and preparative scale thin layer chromatography (TLC), flash column chromatography, solvent extraction, UV-Vis spectroscopy, Infra-Red spectroscopy and mass spectrometry during those developments.
While Perkins previously did research at Arkansas State University Biosciences Institute, this was her first undergraduate research experience.
“When I was in high school, I did not quite understand the science I was doing,” she said, “but here, with my undergraduate classes that I have taken, I understand a lot more of what I am doing.”
That knowledge made the experience more fun for her.
“I am able to learn more about chemistry from what I am doing in the lab, and it makes me feel very prepared for my future classes at Lyon.”
Perkins continued, “I am also doing science I enjoy more than I did in high school, which makes it more fun.”
Her courses at Lyon prepared her for some of the lab techniques she used this summer. Now a rising sophomore, she believes her lab experience will help her in future courses.
“Some of the things I have done, I already knew the basics from some of my general chemistry classes,” Perkins said. “I think understanding the applications of what I have done this summer will really help me understand the in-class material when I take Organic Chemistry.”
She spent most of the summer developing molecules with azido or alkyne groups. One of her favorite moments from her summer research was when she successfully combined two different modified naphthoquinones, which contained alkyne and azido reactive groups she developed in the lab, into a new hybrid product by using click chemistry.
“It ended up working! This new click product will hopefully help in fighting against lung cancer.”
Lung cancer remains the most common cancer worldwide, in the United States, and in Arkansas. According to the American Cancer Society and the International Agency for Research on Cancer, more people die as a result of lung cancer each year than from breast, colorectal and prostate cancer combined.
The molecules Perkins helped develop are being tested for their anticancer and antimicrobial activities at University of Arkansas for Medical Sciences (UAMS), where Lyon has research collaborations.
She plans to continue doing undergraduate research this semester. Her goal is to eventually obtain her Ph.D. in chemistry.
“I am unsure what I quite want to do for my future, but I think I might want to do research after how much I enjoyed researching this summer.”